Alabama running back Trent Richardson ran for a career-best 183 yards and set another a career best with four touchdowns. Richardson put the Rebels (2-4, 0-3 SEC) away with a 76-yard run midway through the third quarter and now leads the nation with six straight 100-yard games.
Randall Mackey's 59-yard pass completion to the 2 on the game's fourth play helped the Rebels take a 7-0 lead on their opening drive. Jeff Scott capped the successful start with a one-yard scoring run for his team-leading seventh total touchdown of the season.
But after giving up 72 yards on that drive's five plays, the Crimson Tide (7-0, 4-0) held Ole Miss without a yard for the rest of the half, a total of 18 plays, on the way to a 17-7 lead.
Alabama turned up the offensive intensity in the second half, scoring on five of six offensive possessions. The sixth ended deep in Ole Miss territory as time expired.
Richardson and Jalston Fowler, who finished with 125 yards rushing nad two second-half TDs, helped the Tide rush for 389 yards (9.3 yards per carry) and Alabama finished with 615 total. The Rebels didn't find much room in the second half either, and finished with 113 total yards and just 28 rushing.
The Crimson Tide forced two turnovers, sacked Mackey five times and stopped the Rebels' only real second-half threat with a goal-line stand.
The Rebels, already without four players due to suspension, lost two key defenders to injuries as well. Cornerback Marcus Temple fractured his right ankle in the first half and defensive end Wayne Dorsey was lost in the second half to an unspecified injury.